HelloProtein™

Most existing technologies for protein analysis rely on measuring changes of optical properties.

This can be a change in the refractive index in the case of SPR or a shift in the interference pattern for BLI. Optical measurements are extremely accurate, but this accuracy comes at the cost of complex optical components. These are not only very costly, but prone to failure and without any potential for miniaturisation.

Our goal is to democratise protein characterisation, by making it  significantly more affordable, easier to use and faster than ever before. Driven by advances in nanotechnology, microelectronics and advanced algorithms, we have developed an entirely different approach.

We use electrical detection only - no more optical components. The microchip at the heart of the sensor is capable of analysing proteins and their interactions in a simple and affordable plug & play tool that fits into the palm of your hand.

Benefits

Plug & play
A simple handheld device that does not require any installation
Molecule size indifferent
Our detection method does not depend on molecular weight or size
Real-time signal
A real-time signal enables observing binding events and measuring binding affinity
Affordable
Get started with a reader and our sensors for less than $15,000
High sensitivity
Detect proteins, antibodies, and small molecules down to low nanomolar concentration
Results in an afternoon
Get results in an afternoon - why wait for weeks to receive results from an external lab?

Specifications

Sensitivity
< low nanomolar
Available surfaces
Amine, Streptavidin, Protein A
Temperature range
+10 to +30 C
Possible analytes
Proteins, Antibodies, Small molecules*, DNA*
Data points
K-on, K-off, binding affinity, concentration measurements

The technology

The sensor
Our sensor, a stamp sized microchip, detects the electrical charge of biomolecules. Binding events are directly translated into a digital signal. We are building on the technology driving field effect transistors (FET), the device that has enabled the computational revolution of the 20th century, and combined it with the most recent advances in nanotechnology to create the bio-FET. 

Picture of FET scheme

Powered by graphene

The bio-FET is driven by a single atomic layer of a carbon crystal - graphene. Changes in the electrical charges in its environment affect the electrical properties of the graphene layer. Thus, we are able to detect minute electrical charge changes allowing the detection of biomolecule binding with high precision.

Powered by cutting-edge research

Building on years of research at the University of Cambridge, we have developed the methods to produce and manipulate these atomically thin crystals with the required precision.

Combining this with a method for stable and fast surface functionalisation, we have been able to develop our newest tool - introducing HelloProtein.

RESEARCH SUPPORT INSTITUTES