Currently, most analytical instruments predominantly use optical technology and thus require complex and bulky equipment that leads to high running costs and maintenance schedules. Our approach is based on an all-electric detection - no more optical components! The microchip at the heart of the sensor is capable of analysing proteins and their interactions in a simple, affordable, benchtop plug & play plate reader - HexagonFab Bolt.
Our goal is to democratise protein characterisation, by making it significantly more affordable, easier to use and faster than ever before. Driven by advances in nanotechnology, microelectronics and advanced algorithms, we have developed an entirely different approach.
Bolt uses silicon dip-in-well sensors with a sensing zone at their tip that enables current to flow. The sensor operates on the principle of Redox Electrochemical Detection (RED) technology, which measures the alteration in current that occurs when molecules interact with its electrosensitive surface. The signal that is picked up by the sensor is electrical, no optical components needed.
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Building on years of research at the University of Cambridge, we have developed the methods to produce and manipulate these atomically thin crystals with the required precision.
Together with a method for stable and fast surface functionalisation, cutting-edge engineering and enabling software, we are bringing new tools to advance the research and development of novel therapeutics.